A strange myalgia

A 70-year-old man was admitted in our hospital with mild fever, pain, myalgia. His eosinophil count was high, leading to a diagnosis of hypereosinophilic syndrome. This case report gives rise to many questions regarding diagnosis and correct management of eosinophilic myopathies

An excluded diagnosis

We describe a 50-years-old patient with septic fever of unidentifiable source, following resection for rectal adenocarcinoma. He has been in treatment for sepsi two months before. Blood coltures, an accurate amanestic analysis and a transesophageal echocardiography were the major tools for the diagnosis of this disease. After the diagnosis of infective endocarditis had been excluded, antibiotic treatment (with teicoplanin and rifampicine) was given for the presence of Staphylococcus epidermidis. The previous pacemaker system was removed and a DDD pacemaker was implanted

Differential diagnosis of small bowel occlusions

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, and microsatellite instability (MSI). Patients with Lynch syndrome have a markedly increased risk of colorectal cancer. We report a case of a 28-year-old male with Lynch syndrome; the case allows to describe clinical manifestations and diagnostic criteria of this syndrome, and to underline the importance of genetics in the diagnosis of this disease

Applying Space Data to the Analysis of the Economic Impact of Covid-19 Restrictions

The objective of this research is to study the impact of Covid-19 restrictions on the Italian economy based on space data on representative Italian ports. We posit that port activity has a mediation effect on Covid-19 restrictions’ impact on the Italian economy. To study port activity we leverage space data and, in particular, earth observation AIS data, which provide different types of information describing a port’s activity, such as the number of ships in a port at different points in time and their type. We complement these data with other sources of data, including traffic and mobility data, as well official sources of information on port economics and on the more general trends of the Italian economy. To test our hypotheses, we focus on two large Italian ports, Genoa (Liguria) and Gioia Tauro (Calabria). Our empirical analyses confirm that port activity has a mediation effect on Covid-19 restrictions’ impact on the Italian economy. The mediation effect has been found to be partial, as Covid-19 restrictions direct impact on the Italian economy remains significant when port activity is added to the correlation model

Open University vs. Consorzio Nettuno: An Institutional Analysis of Two Technology Enabled Higher Educational Systems

Assuming a rational perspective, the adoption and development of a new organisational technology can be viewed as a way to achieve an higher level of efficiency by finding the best way to fully exploit its potential. In other words, one might sustain that since organisations do initially ignore how to best deal with an innovative technology, they engage in a trial and error learning process that finally leads to the x-efficiency frontier. Once this knowledge is achieved, it will probably be spread around by external agents (e.g. consultants) enabling an imitative process. Thus in the long run all organisations will make almost the same efficient use of a mature organisational technology. In this paper we tried to explore how the same technology (eLearning) has been adopted by two diverse educational organisations. The patterns of development have been studied across time to verify if a progressive convergence has occurred. Results are providing some useful insights on what variables must be paid attention to when transferring a technological organisational innovation in a different settin

Charge Transfer and dddd excitations in AgF2_{2}

Charge transfer (CT) insulators are the parent phase of a large group of today's unconventional high temperature superconductors. Here we study experimentally and theoretically the interband excitations of the CT insulator silver fluoride AgF$_2$, which has been proposed as an excellent analogue of oxocuprates. Optical conductivity and resonant inelastic x-ray scattering (RIXS) on AgF$_2$ polycrystalline sample show a close similarity with that measured on undoped La$_2$CuO$_4$. While the former shows a CT gap $\sim$3.4~eV, larger than in the cuprate, $dd$-excitations are nearly at the same energy in the two materials. DFT and exact diagonalization cluster computations of the multiplet spectra show that AgF$_2$ is more covalent than the cuprate, in spite of the larger fundamental gap. Furthermore, we show that AgF$_2$ is at the verge of a charge transfer instability. The overall resemblance of our data on AgF$_2$ to those published previously on La$_2$CuO$_4$ suggests that the underlying CT insulator physics is the same, while AgF$_2$ could also benefit from a proximity to a charge density wave phase as in BaBiO$_3$. Therefore, our work provides a compelling support to the future use of fluoroargentates for materials' engineering of novel high-temperature superconductors.Comment: 13 pages, 9 Figures (including SI

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Understanding immune cells in tertiary lymphoid organ development:it is all starting to come together

Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer and allograft rejection. These highly ordered structures resemble the cellular composition of lymphoid follicles typically associated with the spleen and lymph node compartments. Although TLOs within tissues show varying degrees of organisation, they frequently display evidence of segregated T and B cell zones, follicular dendritic cell networks, a supporting stromal reticulum and high endothelial venules. In this respect, they mimic the activities of germinal centres and contribute to the local control of adaptive immune responses. Studies in various disease settings have described how these structures contribute to either beneficial or deleterious outcomes. While the development and architectural organisation of TLOs within inflamed tissues requires homeostatic chemokines, lymphoid and inflammatory cytokines and adhesion molecules, our understanding of the cells responsible for triggering these events is still evolving. Over the past 10-15 years novel immune cell subsets have been discovered that have more recently been implicated in the control of TLO development and function. In this review we will discuss the contribution of these cell types and consider the potential to develop new therapeutic strategies that target TLOs

La valutazione dei top performes bancari

L'articolo procede ad una analisi delle performance di borsa e dei multipli di valore nel settore bancario